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Page 1
Association of F11R polymorphisms and gene expression with primary Sjogren's syndrome patients.
Fang TJ, Li RN, Lin YZ, Lin CH, Tseng CC, Sung WY, Ou TT, Wu CC, Yen JH. Fang TJ, et al. Int J Rheum Dis. 2021 May;24(5):681-686. doi: 10.1111/1756-185X.14095. Epub 2021 Mar 29. Int J Rheum Dis. 2021. PMID: 33780157
AIMS: F11R gene encodes junctional adhesion molecule-A protein (JAM-A), which is expressed in various types of cells and is involved in leukocyte extravasation during inflammation. Sjogren's syndrome (SS) is a chronic systemic inflammatory disease that involves lymp …
AIMS: F11R gene encodes junctional adhesion molecule-A protein (JAM-A), which is expressed in various types of cells and is involved …
F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?
Kamola P, Babinska A, Przygodzki T. Kamola P, et al. Platelets. 2023 Dec;34(1):2214618. doi: 10.1080/09537104.2023.2214618. Platelets. 2023. PMID: 37246517 Free article. Review.
F11R/JAM-A is present in epithelial cells, endothelial cells, leukocytes, and blood platelets. ...In leukocytes, F11R/JAM-A was shown to play role in their transmigration through the vascular wall. ...
F11R/JAM-A is present in epithelial cells, endothelial cells, leukocytes, and blood platelets. ...In leukocytes, F11R/JAM-A wa
JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function.
Kakogiannos N, Ferrari L, Giampietro C, Scalise AA, Maderna C, Ravà M, Taddei A, Lampugnani MG, Pisati F, Malinverno M, Martini E, Costa I, Lupia M, Cavallaro U, Beznoussenko GV, Mironov AA, Fernandes B, Rudini N, Dejana E, Giannotta M. Kakogiannos N, et al. Circ Res. 2020 Sep 25;127(8):1056-1073. doi: 10.1161/CIRCRESAHA.120.316742. Epub 2020 Jul 15. Circ Res. 2020. PMID: 32673519 Free PMC article.
Their composition and integrity are affected in pathological contexts, such as inflammation and tumor growth. JAM-A (junctional adhesion molecule A) is a transmembrane component of tight junctions with a role in maintenance of endothelial barrier function, although how thi …
Their composition and integrity are affected in pathological contexts, such as inflammation and tumor growth. JAM-A (junctional adhes …
Silencing of the F11R gene reveals a role for F11R/JAM-A in the migration of inflamed vascular smooth muscle cells and in atherosclerosis.
Azari BM, Marmur JD, Salifu MO, Cavusoglu E, Ehrlich YH, Kornecki E, Babinska A. Azari BM, et al. Atherosclerosis. 2010 Sep;212(1):197-205. doi: 10.1016/j.atherosclerosis.2010.05.014. Epub 2010 May 19. Atherosclerosis. 2010. PMID: 20627246
Neither the F11R message nor protein was expressed in non-stimulated SMCs. The functional role of F11R in SMCs' migration was studied in cytokine-stimulated SMCs by interference of F11R expression with siRNA. Silencing of the F11R gene of cytokines-tre …
Neither the F11R message nor protein was expressed in non-stimulated SMCs. The functional role of F11R in SMCs' migration was …
Transcription and translation of human F11R gene are required for an initial step of atherogenesis induced by inflammatory cytokines.
Azari BM, Marmur JD, Salifu MO, Ehrlich YH, Kornecki E, Babinska A. Azari BM, et al. J Transl Med. 2011 Jun 26;9:98. doi: 10.1186/1479-5876-9-98. J Transl Med. 2011. PMID: 21703019 Free PMC article.
Previous reports demonstrated that exposure of ECs to pro-inflammatory cytokines causes insertion of F11R molecules into the luminal surface of ECs, ensuing with homologous interactions between F11R molecules of platelets and ECs, and a resultant adhesion of platele …
Previous reports demonstrated that exposure of ECs to pro-inflammatory cytokines causes insertion of F11R molecules into the luminal …
A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis.
Babinska A, Clement CC, Przygodzki T, Talar M, Li Y, Braun M, Wzorek J, Swiatkowska M, Ehrlich YH, Kornecki E, Watala C, Salifu MO. Babinska A, et al. Atherosclerosis. 2019 May;284:92-101. doi: 10.1016/j.atherosclerosis.2019.02.014. Epub 2019 Feb 22. Atherosclerosis. 2019. PMID: 30877938
BACKGROUND AND AIMS: The F11 Receptor (F11R), AKA Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A), is an adhesion protein constitutively expressed on the membrane surface of circulating platelets and the luminal surface of inflamed endothelial cells (EC). ...Our …
BACKGROUND AND AIMS: The F11 Receptor (F11R), AKA Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A), is an adhesion protein …
Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease.
Rath D, Rapp V, Schwartz J, Winter S, Emschermann F, Arnold D, Rheinlaender J, Büttcher M, Strebl M, Braun MB, Altgelt K, Uribe ÁP, Schories C, Canjuga D, Schaeffeler E, Borst O, Schäffer TE, Langer H, Stehle T, Schwab M, Geisler T, Gawaz M, Chatterjee M. Rath D, et al. JACC Basic Transl Sci. 2022 May 23;7(5):445-461. doi: 10.1016/j.jacbts.2022.03.003. eCollection 2022 May. JACC Basic Transl Sci. 2022. PMID: 35663628 Free PMC article.
Homozygous carriers of the minor alleles (F11R-SNVs rs2774276, rs790056) show enhanced levels of thrombo-inflammatory sJAM-A. Both F11R-SNVs and sJAM-A are associated with worse prognosis for recurrent myocardial infarction in CAD patients. ...
Homozygous carriers of the minor alleles (F11R-SNVs rs2774276, rs790056) show enhanced levels of thrombo-inflammatory sJAM-A. Both …
Expression of Inflammation-related Intercellular Adhesion Molecules in Cardiomyocytes In Vitro and Modulation by Pro-inflammatory Agents.
El-Battrawy I, Tülümen E, Lang S, Akin I, Behnes M, Zhou X, Mavany M, Bugert P, Bieback K, Borggrefe M, Elmas E. El-Battrawy I, et al. In Vivo. 2016 May-Jun;30(3):213-7. In Vivo. 2016. PMID: 27107077
BACKGROUND: Cell-surface adhesion molecules regulate multiple intercellular and intracellular processes and play important roles in inflammation by facilitating leukocyte endothelial transmigration. Whether cardiomyocytes express surface-adhesion molecules related to in
BACKGROUND: Cell-surface adhesion molecules regulate multiple intercellular and intracellular processes and play important roles in infla
HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood-Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration.
Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. Dental C, et al. J Immunol. 2017 Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19. J Immunol. 2017. PMID: 27994072
Therefore, the risks and benefits of using broad-spectrum LRAs need to be carefully evaluated, particularly in the CNS, where inflammation and leukocyte transmigration must be tightly regulated. ...Prostratin and bryostatin-1 could thus be considered as potent regulators o …
Therefore, the risks and benefits of using broad-spectrum LRAs need to be carefully evaluated, particularly in the CNS, where inflammatio
Genomic structure, organization and promoter analysis of the human F11R/F11 receptor/junctional adhesion molecule-1/JAM-A.
Sobocki T, Sobocka MB, Babinska A, Ehrlich YH, Banerjee P, Kornecki E. Sobocki T, et al. Gene. 2006 Jan 17;366(1):128-44. doi: 10.1016/j.gene.2005.08.025. Epub 2005 Dec 5. Gene. 2006. PMID: 16337094
In addition, the F11R plays a critical role in the function of endothelial cells and in platelet adhesion to inflamed endothelium. In the present study, we used partial sequences of the human F11R gene, F11R cDNAs, and information in unannotated human genome …
In addition, the F11R plays a critical role in the function of endothelial cells and in platelet adhesion to inflamed endothelium. In …
75 results